Chrysin suppress immune responses and protects from experimental autoimmune encephalomyelitis in mice. - GreenMedInfo Summary

n/a

Abstract Title:

Chrysin suppress immune responses and protects from experimental autoimmune encephalomyelitis in mice.

Abstract Source:

J Neuroimmunol. 2019 Oct 15 ;335:577007. Epub 2019 Jul 16. PMID: 31376787

Abstract Author(s):

Lucian Del Fabbro, Marcelo Gomes de Gomes, Leandro Cattelan Souza, André Rossito Goes, Silvana Peterini Boeira, Mauro Schneider Oliveira, Ana Flávia Furian, Cristiano Ricardo Jesse

Article Affiliation:

Lucian Del Fabbro

Abstract:

We investigated the effects of chrysin in the experimental autoimmune encephomyelitis (EAE), a multiple sclerosis (MS) animal model. EAE was induced using myelin oligodendrocyte glycoprotein (MOG) 35-55 peptide in C57BL/6 mice. Chrysin reduced weight loss, attenuated clinical signs and blunted the EAE-induced increase in histone deacetylase (HDCA) activity, glycogen synthase kinase-3β (GSK-3β) levels and pro-inflammatory cytokine levels as well as in the EAE-induced decrease in histone acetyltransferases 3 and 4 (HAT3, HAT4). Altogether, results demonstrate beneficial effects and potential targets of chrysin in EAE.

Article Published Date : Oct 14, 2019

Study Type : Animal Study

Additional Links

Substances : Chrysin : CK(147) : AC(93)

Diseases : Multiple Sclerosis : CK(1438) : AC(288)

Pharmacological Actions : Anti-Inflammatory Agents : CK(12461) : AC(4729)

Print Options

Some features are currently member only features. If you are already a member, please login. Otherwise, click here to become a member.

Printer-friendly version
Send to friend
PDF version

Chrysin suppress immune responses and protects from experimental autoimmune encephalomyelitis in mice. - GreenMedInfo Summary

Print Options

Key Research Topics

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.