Oxidative stress-mediated myocardiotoxicity of ciprofloxacin and ofloxacin in juvenile rats.
Drug Chem Toxicol. 2009;32(3):238-42. PMID: 19538020
Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Eskişehir, Turkey. firstname.lastname@example.org
In this study, evaluation of the myocardiotoxic effect potential of ciprofloxacin and ofloxacin in juvenile rats and the role of oxidative stress in heart toxicity was conducted. Doses (25 and 50 mg/kg) of each drug were administered to the rats for 1 week. Serum biochemical cardiotoxicity parameters and tissue malondialdehyde and nitric oxide levels were measured. All measured parameters were found elevated in the drug-treated rats, being the highest in the 50-mg/kg ofloxacin-treated rats. Ciprofloxacin and ofloxacin may cause myocardiotoxicity by inducing the oxidative stress in the heart, and nitric oxide is partly responsible for this toxicity.