Abstract Title:

Anti-hepatitis C virus effect of citrus unshiu peel and its active ingredient nobiletin.

Abstract Source:

Am J Chin Med. 2005;33(1):87-94. PMID: 15844836

Abstract Author(s):

Megumi Suzuki, Kenroh Sasaki, Fumihiko Yoshizaki, Katsuji Oguchi, Min Fujisawa, Jong-Chol Cyong


hepatitis C virus (HCV) absorption in MOLT-4 cells (a human lymphoblastoid leukemia cell line). By reverse transcription polymerase chain reaction (RT-PCR), we showed that both the ethyl acetate layer of Citrus unshiu peel extract and fraction 7 decreased HCV absorption in MOLT-4 cells. Furthermore, we demonstrated that 3',4',5,6,7,8-hexamethoxyflavone (nobiletin) is the active ingredient that markedly inhibited HCV infection in MOLT-4 cells.

Study Type : In Vitro Study

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