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Abstract Title:

Cloudy Apple Juice Fermented byPrevents Obesity via Modulating Gut Microbiota and Protecting Intestinal Tract Health.

Abstract Source:

Nutrients. 2021 Mar 17 ;13(3). Epub 2021 Mar 17. PMID: 33802755

Abstract Author(s):

Mengzhen Han, Meina Zhang, Xiaowei Wang, Xue Bai, Tianli Yue, Zhenpeng Gao

Article Affiliation:

Mengzhen Han


Obesity and hyperglycemia are two serious chronic diseases that are increasing in incidence worldwide. This research aimed to develop a fermented cloudy apple juice with good hyperglycemia intervention activities. Here, cloudy apple juice (CAJ), cloudy apple juice rich in polyphenols (CAJP) and fermented cloudy apple juice rich in polyphenols (FCAJP) were prepared sequentially, and then the effects of the three apple juices on weight, lipid level, gut microbiota composition and intestinal tract health were evaluated for obese mice induced by a high-fat diet. The research findings revealed that the FCAJP showed potential to inhibit the weight gain of mice, reduce fat accumulation, and regulate the blood lipid levels of obese mice by decreasing the ratio of the Firmicutes/Bacteroidotas, improving the Sobs, Ace, and Chao indexes of the gut microbiota and protecting intestinal tract health. In addition, the FCAJP augmented the abundance of Akkermansia and Bacteroides, which were positively related to SCFAs in cecal contents. This study inferred that FCAJP could be developed as a healthy food for preventing obesity and hyperglycemia.

Study Type : Animal Study

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