Abstract Title:

Coenzyme Q10 Suppresses TNF-α-Induced Inflammatory Reaction In Vitro and Attenuates Severity of Dermatitis in Mice.

Abstract Source:

Inflammation. 2015 Sep 4. Epub 2015 Sep 4. PMID: 26341816

Abstract Author(s):

Weiwei Li, Xiaojuan Wu, Xiangling Xu, Wenhan Wang, Sijia Song, Ke Liang, Min Yang, Linlin Guo, Yunpeng Zhao, Ruifeng Li

Article Affiliation:

Weiwei Li

Abstract:

Anti-oxidant coenzyme Q10 (Co-Q10) is commonly used in clinic. Recently, Co-Q10 was reported to antagonize TNF-α-induced inflammation and play a protective role in various inflammatory conditions. However, its role in dermatitis is unknown. Herein, RAW264.7 macrophage cell line was cultured with stimulation of TNF-α, and administration of Co-Q10 alleviated TNF-α-mediated inflammatory reaction in vitro. Furthermore, oxazolone-induced dermatitis mice model was established, and treatment of Co-Q10 markedly attenuated dermatitis phenotype in this mice model. Moreover, the protective role of Co-Q10 in vitro and in dermatitis was probably due to its repression on NF-κB signaling. Collectively, Co-Q10 mayrepresent a potential molecular target for prevention and treatment of inflammatory skin diseases.

Study Type : Animal Study, In Vitro Study

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