A cocktail of betulinic acid, parthenolide, honokiol and ginsenoside Rh2 in liposome systems for lung cancer treatment.
Nanomedicine (Lond). 2020 Jan ;15(1):41-54. PMID: 31868113
Lung cancer has a very high incidence rate, and thus, there is an urgent need for novel and effective therapies.In this study, we proposed a potential treatment option by combining four natural products in liposome systems.studies indicated that the combination of betulinic acid, parthenolide, honokiol and ginsenoside Rh2 exhibited a synergistic action. When these four natural products were loaded into liposome systems, we observed an increased effect. The relative action was also observed. The cisplatin group presented obvious kidney damage, whereas both cocktail therapy and cocktail liposome therapy were safer.Therefore, we propose cocktail liposome systems may provide a more efficient and safer treatment for lung cancer.