Abstract Title:

Cocoa ingestion protects plasma lipids in healthy males against ex vivo oxidative conditions: A randomized clinical trial.

Abstract Source:

Clin Nutr ESPEN. 2018 Aug ;26:1-7. Epub 2018 May 30. PMID: 29908675

Abstract Author(s):

Manuel Barrios, Luis C Orozco, Elena E Stashenko

Article Affiliation:

Manuel Barrios


The effects of in vivo cocoa-based supplementation were studied as a preconditioning treatment for ex vivo acute oxidative conditions in a controlled randomized clinical trial. Subjects were 100 healthy young men at Universidad Industrial de Santander blinded to the intervention and divided into two groups: The intervention group (n = 50) receiving 30 g of cocoa powder and 50 g of dark chocolate/d for 1 week with the remaining subjects receiving placebo. Cocoa products preconditioning for 1 week resulted in modifications in the susceptibility of plasma lipids over ex vivo oxidative conditions with effects of i) a significant increase in the oxidative resistance of plasma lipids measured by dienes formation (4.2, CI: 0.18, 8.2; P = 0.04), and ii) a significant reduction in the production of toxic aldehydes as established by a decrease in the content of hexanal, quantified by gas chromatography (-0.22, CI: -0.38, -0.05; P = 0.009). The in vivo cocoa-based preconditioning demonstrated protective properties against ex vivo oxidative modifications, improving total plasma lipids resistance to oxidation and protecting plasma lipids against great acute oxidative insult in comparison with placebo. This trial was registered at clinical clinicaltrials.gov as NCT01347450.

Study Type : Human Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.