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Abstract Title:

Antidepressant, antioxidant and neurotrophic properties of the standardized extract of Cocos nucifera husk fiber in mice.

Abstract Source:

J Nat Med. 2016 Jul ;70(3):510-21. Epub 2016 Feb 8. PMID: 26857134

Abstract Author(s):

Eliane Brito Cortez Lima, Caren Nádia Soares de Sousa, Germana Silva Vasconcelos, Lucas Nascimento Meneses, Yuri Freitas E Silva Pereira, Naiara Coelho Ximenes, Manuel Alves Santos Júnior, Natália Castelo Branco Matos, Rayanne Brito, Diogo Miron, Luzia Kalyne Almeida Moreira Leal, Danielle Macêdo, Silvânia Maria Mendes Vasconcelos

Article Affiliation:

Eliane Brito Cortez Lima

Abstract:

The plant Cocos nucifera and its derivatives have shown antidepressant-like effects, although its hydroalcoholic extract has not been studied with this end in mind. Therefore, we decided to determine the antidepressant-like effects of the standardized hydroalcoholic extract of Cocos nucifera husk fiber (HECN) as well as oxidative alterations in the prefrontal cortex (PFC), hippocampus (HC) and striatum (ST), and the levels of brain-derived neurotrophic factor (BDNF) in the HC of mice. The extract was characterized based on the content of total polyphenols as well as two phenol compounds-catechin and chlorogenic acid-by HPLC-PDA. Male animals were treated per os (p.o.) for 7 days with distilled water or HECN (50, 100 or 200 mg/kg), or intraperitoneally with vitamin E (Vit E 400 mg/kg). One hour after the last drug administration, the animals were submitted to the open field test, forced swimming test (FST), tail suspension test (TST) and, immediately after the behavioral tests, had their brain removed for neurochemical determinations. The results showed that HECN100 decreased the immobility time in the FST and TST presenting, thus demonstrating an antidepressant-like effect. The administration of HECN decreased malondialdehyde levels in all doses and brain areas studied with the exception of HECN50 in the HC. The administration of HECN also decreased nitrite levels in all doses and brain regions studied. HECN100 also increased the levels of BDNF in HC of mice. In conclusion, we demonstrated that HECN has antidepressant-like properties, probably based onits antioxidant and neurotrophic effects, and is thus relevant for the treatment of depression.

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