Abstract Title:

Antihyperglycemic and antioxidative effects of a herbal formulation of Radix Astragali, Radix Codonopsis and Cortex Lycii in a mouse model of type 2 diabetes mellitus.

Abstract Source:

Clin Exp Immunol. 2009 Apr;156(1):78-87. Epub 2009 Jan 21. PMID: 19107854

Abstract Author(s):

Judy Yuet-Wa Chan, Fung-Chun Lam, Ping-Chung Leung, Chun-Tao Che, Kwok-Pui Fung

Article Affiliation:

Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.

Abstract:

There is emerging evidence that the generation of reactive oxygen species (ROS), which leads to dysfunction of pancreatic beta-cells, is a major factor in the development of type 2 diabetes mellitus. Antioxidation is one of the therapeutic strategies to overwhelm the imbalance in ROS production. In this study, a herbal formulation SR10, comprising Radix Astragali, Radix Codonopsis and Cortex Lycii, was examined for its antidiabetic and antioxidative effects using the diabetic +db/+db mouse model. The results showed that SR10 was effective in decreasing the blood glucose level in chronic treatment by improving beta-cell function. The activities and expression of antioxidant enzymes, catalase and superoxide dismutase, were up-regulated when treated with SR10. Moreover, SR10 treatment did not exhibit any toxic effect to the host.

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