Coenzyme Q10 levels as high as 3,000 mg a day are safe and well-tolerated in ALS patients. - GreenMedInfo Summary
Tolerance of high-dose (3,000 mg/day) coenzyme Q10 in ALS.
Neurology. 2005 Dec 13;65(11):1834-6. PMID: 16344537
Neurology Clinical Trials Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. email@example.com
An open-label dose-escalation trial was performed to assess the safety and tolerability of high doses of coenzyme Q10 (CoQ10) in ALS. CoQ10, a cofactor in mitochondrial electron transfer, may improve the mitochondrial dysfunction in ALS. In this study, CoQ10 was safe and well tolerated in 31 subjects treated with doses as high as 3,000 mg/day for 8 months.