Abstract Title:

Clinical response of myelodysplastic syndromes patients to treatment with coenzyme Q10.

Abstract Source:

Leuk Res. 2007 Jan;31(1):19-26. Epub 2006 Oct 24. PMID: 17064768

Abstract Author(s):

Naomi Galili, Eric V Sechman, Jan Cerny, Murtaza Mehdi, Muhammad Mumtaz, Peter Westervelt, Jessica Maguire, Azra Raza

Abstract:

The myelodysplastic syndromes (MDS) are a collection of hematopoietic disorders with varying degrees of mono- to trilineage cytopenias and bone marrow dysplasia. In recent years much progress has been made in the treatment of MDS and there are now several therapeutic compounds used with varying levels of success. These compounds typically cause side effects that make them unattractive for treatment of patients in the early stages of MDS. Naturally occurring compounds that are not toxic may provide a means to treat patients in the initial stages of disease. We conducted a pilot study to test the efficacy of coenzyme Q10 (coQ10) in MDS patients with low to intermediate-2 risk disease. A variety of responses were observed in 7 of 29 patients including two trilineage and two cytogenetic responses. Sequencing mitochondrial DNA (mtDNA) from pretreatment bone marrows showed multiple mutations, some resulting in amino acid changes, in 3/5 nonresponders, 1/4 responders and in two control samples. We conclude that coQ10 may be of clinical benefit in a subset of MDS patients, but responders cannot be easily pre-selected on the basis of either the conventional clinical and pathologic characteristics or mtDNA mutations.

Study Type : Human Study

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