Coenzyme Qsupplementation reduces oxidative stress and decreases antioxidant enzyme activity in children with autism spectrum disorders.
Psychiatry Res. 2018 Apr 4 ;265:62-69. Epub 2018 Apr 4. PMID: 29684771
Antioxidants and oxidative stress can participate in pathobiochemical mechanisms of autism spectrum disorders (ASDs). The aim was to identify the effects of early CoQsupplementation on oxidative stress in children with ASDs. Ninety children with ASDs were included in this study, based on DSM-IV criteria and using Childhood Autism Rating Scale (CARS) scores. Concentrations of CoQ, MDA, total antioxidant status (TAS) assay, and antioxidant enzymes (superoxide dismutase or SOD and glutathione peroxidase or GPx) activity were determined in serum before and after 100 days of supportive therapy with CoQat daily doses of 30 and 60 mg. Data on children's behavior were collected from parents and babysitters. CoQsupportive therapy was determined after three months with daily dose 2ͯ 30 mg improved oxidative stress in the children with ASDs. A relation was seen between serum MDA (r = 0.668) and TAS (r = 0.007), and antioxidant enzymes (SOD [r = 0.01] and GPx [r = 0.001]) activity and CARS score. Based on the results, high doses of CoQcan improve gastrointestinal problems (P = 0.004) and sleep disorders (P = 0.005) in children with ASDs with an increase in the CoQof the serum. We concluded that the serum concentration of CoQand oxidative stress could be used as relevant biomarkers in helping the improvement of ASDs.