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Abstract Title:

Coffee consumption and risk of prostate cancer: a systematic review and meta-analysis.

Abstract Source:

BMJ Open. 2021 01 11 ;11(2):e038902. Epub 2021 Jan 11. PMID: 33431520

Abstract Author(s):

Xiaonan Chen, Yiqiao Zhao, Zijia Tao, Kefeng Wang

Article Affiliation:

Xiaonan Chen

Abstract:

OBJECTIVES: To conduct a systematic review with meta-analysis of cohort studies to evaluate the association of coffee consumption with the risk of prostate cancer.

DATA SOURCES: PubMed, Web of Science and Embase were searched for eligible studies up to September 2020.

STUDY SELECTION: Cohort studies were included.

DATA EXTRACTION AND SYNTHESIS: Two researchers independently reviewed the studies and extracted the data. Data synthesis was performed via systematic review and meta-analysis of eligible cohort studies. Meta-analysis was performed with the""and""commands in Stata 14.0.

MAIN OUTCOMES AND MEASURES: Prostate cancer was the main outcome. It was classified as localised prostate cancer which included localised or non-aggressive cancers; advanced prostate cancer which included advanced or aggressive cancers; or fatal prostate cancer which included fatal/lethal cancers or prostate cancer-specific deaths.

RESULTS: Sixteen prospective cohort studies were finally included, with 57 732 cases of prostate cancer and 1 081 586 total cohort members. Higher coffee consumption was significantly associated with a lower risk of prostate cancer. Compared with the lowest category of coffee consumption, the pooled relative risk (RR) was 0.91 (95% CI 0.84 to 0.98), I= 53.2%) for the highest category of coffee consumption. There was a significant linear trend for the association (p=0.006 for linear trend), with a pooled RR of 0.988 (95% CI 0.981 to 0.995) for each increment of one cup of coffee per day. For localised, advanced and fatal prostate cancer, the pooled RRs were 0.93 (95% CI 0.87 to 0.99), 0.88 (95% CI 0.71 to 1.09) and 0.84 (95% CI 0.66 to 1.08), respectively. No evidence of publication bias was indicated in this meta-analysis.

CONCLUSIONS: This study suggests that a higher intake of coffee may be associated with a lower risk of prostate cancer.

Study Type : Meta Analysis, Review

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Sayer Ji
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