n/a
Article Publish Status: FREE
Abstract Title:

Coffee prevents fatty liver disease induced by a high-fat diet by modulating pathways of the gut-liver axis.

Abstract Source:

J Nutr Sci. 2019 ;8:e15. Epub 2019 Apr 22. PMID: 31037218

Abstract Author(s):

Paola Vitaglione, Giovanna Mazzone, Vincenzo Lembo, Giuseppe D'Argenio, Antonella Rossi, Maria Guido, Marcella Savoia, Federico Salomone, Ilario Mennella, Francesca De Filippis, Danilo Ercolini, Nicola Caporaso, Filomena Morisco

Article Affiliation:

Paola Vitaglione

Abstract:

Coffee consumption is inversely associated with the risk of non-alcoholic fatty liver disease (NAFLD). A gap in the literature still exists concerning the intestinal mechanisms that are involved in the protective effect of coffee consumption towards NAFLD. In this study, twenty-four C57BL/6J mice were divided into three groups each receiving a standard diet, a high-fat diet (HFD) or an HFD plus decaffeinated coffee (HFD+COFFEE) for 12 weeks. Coffee supplementation reduced HFD-induced liver macrovesicular steatosis ( < 0·01) and serum cholesterol ( < 0·001), alanine aminotransferase and glucose ( < 0·05). Accordingly, liver( < 0·05) and acyl-CoA oxidase-1 ( < 0·05) as well as duodenal ATP-binding cassette (ABC) subfamily A1 () and subfamily G1 () ( < 0·05) mRNA expressions increased with coffee consumption. Compared with HFD animals, HFD+COFFEE mice had more undigested lipids in the caecal content and higher free fatty acid receptor-1 mRNA expression in the duodenum and colon. Furthermore, they showed an up-regulation of duodenal and coloniczonulin-1 ( < 0·05), duodenal claudin ( < 0·05) and duodenal peptide YY ( < 0·05) mRNA as well as a higher abundance ofin the faeces ( < 0·05). HFD+COFFEE mice had an energy intake comparable with HFD-fed mice but starting from the eighth intervention week they gained significantly less weight over time. Data altogether showed that coffee supplementation prevented HFD-induced NAFLD in mice by reducing hepatic fat deposition and metabolic derangement through modification of pathways underpinning liver fat oxidation, intestinal cholesterol efflux, energy metabolism and gut permeability. The hepatic and metabolic benefits induced by coffee were accompanied by changes in the gut microbiota.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.