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Abstract Title:

Anti-HIV diterpenes from Coleus forskohlii.

Abstract Source:

Nat Prod Commun. 2009 Sep;4(9):1173-5. PMID: 19831022

Abstract Author(s):

Hardik S Bodiwala, Sudeep Sabde, Debashis Mitra, Kamlesh Kumar Bhutani, Inder Pal Singh

Article Affiliation:

Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S.A.S. Nagar, Punjab - 160062, India.

Abstract:

Various extracts of the aerial parts of Coleus forskohlii (Labiatae) were prepared and evaluated at their non cytotoxic concentration against HIV-1 NL4-3. Chloroform, ethyl acetate and n-butanol extracts showed 45.6, 66.5 and 37.7% inhibition of HIV, respectively in CEM-GFP cells infected with HIV-1(NL4-3) at 5 microg/mL. Four diterpenes, 1-deoxyforskolin, 1,9-dideoxyforskolin, forskolin and isoforskolin were isolated from the chloroform extract and tested against the virus. Six semi-synthetic derivatives of forskolin have been prepared to study SAR. 1-Deoxyforskolin and forskolin were found to be active against HIV(NL4-3). This is first report of anti HIV activity of this plant and its isolated constituents.

Study Type : In Vitro Study

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