n/a
Abstract Title:

Combination of berberine with ciprofloxacin reduce a multi-resistantstrain biofilm formation by depressing mRNA expressions of,and.

Abstract Source:

J Vet Sci. 2018 Oct 8. Epub 2018 Oct 8. PMID: 30304890

Abstract Author(s):

Chenxi Shi, Minmin Li, Ishfaq Muhammad, Xin Ma, Yicong Chang, Rui Li, Changwen Li, Jingshan He, Fangping Liu

Article Affiliation:

Chenxi Shi

Abstract:

Bacterial biofilms have been demonstrated to be closely related to clinical infections and mainly contribute to drug resistance. Berberine, which is the main component of, has been reported to have efficient antibacterial activity. This study aimed to investigate the potential effect of combination of berberine with ciprofloxacin (CIP) to inhibitbiofilm formation and the effect on the related genes (,,) expressions. The fractional inhibitory concentration index of the combination of berberine with CIP is 0.75 showing a synergistic antibacterial effect. The biofilm adhesion rate and growth curve showed that the multi-resistantstrain had potential ability to form biofilm relative to CVCC528, and the antibiofilm effects were in a dose-dependent manner. Biofilm microstructures were rarely observed at 1/2×MIC/FIC concentrations, and the combination showed stronger antibiofilm effect than each of the antimicrobial agent used alone at 1/4×FIC concentration.,andmRNA expressions were significantly repressed (< 0.01) at 1/2×MIC/FIC concentrations, and the combination repressed mRNA expressions more strongly at 1/4×FIC concentration. The results indicated that the combination of berberine and CIP showed synergistic effect and more effective to inhibitbiofilm formation via repression of,andmRNA expressions.

Study Type : In Vitro Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.