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Article Publish Status: FREE
Abstract Title:

Crosstalk between Fisetin-induced Apoptosis and Autophagy in Human Oral Squamous Cell Carcinoma.

Abstract Source:

J Cancer. 2019 ;10(1):138-146. Epub 2019 Jan 1. PMID: 30662534

Abstract Author(s):

Bong-Soo Park, Nak-Eun Choi, Ji Hye Lee, Hae-Mi Kang, Su-Bin Yu, Hye-Jin Kim, Hyun-Kyung Kang, In-Ryoung Kim

Article Affiliation:

Bong-Soo Park

Abstract:

Fisetin (3,3-,4-,7-tetrahydroxyflavone), a naturally occurring flavonoid, has antioxidant, anti-inflammatory, and anticancer effects. Oral squamous cell carcinoma (OSCC) has a 5-year survival rate lower than that of most other carcinomas, and can create functional and aesthetic problems for the patient. New therapies for OSCC are necessary, and treatment using plant-derived natural substances has recently become a trend. It has been suggested that autophagy may play an important role in cancer therapy. Several studies demonstrated that autophagy inhibition enhances apoptotic cell death. Therefore, autophagy inhibition might be a promising therapeutic method against OSCC. Our results showed that fisetin induced apoptotic cell death in human tongue squamous cell line Ca9-22 could be enhanced by inhibition of autophagy. Thus, autophagy process in fisetin treated OSCC might presumed to play a role of pro-survival. The combination of fisetin and an effective autophagy inhibitor could be a potentially adjuvant and useful treatment for oral cancer.

Study Type : In Vitro Study

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Sayer Ji
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