Article Publish Status: FREE
Abstract Title:

Supplementation Effect of a Combination of Olive (L.) Leaf and Fruit Extracts in the Clinical Management of Hypertension and Metabolic Syndrome.

Abstract Source:

Antioxidants (Basel). 2020 Sep 15 ;9(9). Epub 2020 Sep 15. PMID: 32942738

Abstract Author(s):

Michel P Hermans, Philippe Lempereur, Jean-Paul Salembier, Nathalie Maes, Adelin Albert, Olivia Jansen, Joël Pincemail

Article Affiliation:

Michel P Hermans


BACKGROUND: The role of herbal products in the prevention of cardiovascular disease requires supporting evidence. This open pilot study assessed the effect of 2-month supplementation of a combination of olive leaf and fruit extracts (Tensiofytol, Tilman SA, Baillonville, Belgium) in the clinical management of hypertension and metabolic syndrome (MetS).

METHODS: A total of 663 (pre)-hypertensive patients were enrolled by general practitioners and supplemented for two months with Tensiofytol, two capsules per day (100 mg/d of oleuropein and 20 mg/d of hydroxytyrosol). Systolic and diastolic blood pressures (SBP/DBP) were measured before and after treatment. Markers of MetS, high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), fasting blood glucose (FG) and waist circumference (WC), were also examined.

RESULTS: Significant reductions (<0.0001) in SBP/DBP (13± 10/7.1 ± 6.6 mmHg) were observed and similarly in pre-diabetic and diabetic patients. Improvements in SBP/DPB were independent of age and gender but greater for elevated baseline SBP/DBP. Tensiofytolsupplementation also significantly improved markers of MetS, with a decrease of TG (11%), WC (1.4%) and FG (4.8%) and an increase of HDL-C (5.3%). Minor side effects were reported in 3.2% patients.

CONCLUSIONS: This real-life, observational, non-controlled, non-randomized pilot study shows that supplementation of a combination of olive leaf and fruit extracts may be used efficiently and safely in reducing hypertension and MetS markers.

Study Type : Human Study

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