An combined extract of lotus, white mulberry and radish may be a natural anti-obesity agent. - GreenMedInfo Summary
Anti-Obesity Effect of Extract fromL.,L., andMixture in 3T3-L1 Adipocytes and C57BL/6J Obese Mice.
Foods. 2019 May 19 ;8(5). Epub 2019 May 19. PMID: 31109115
The antioxidant and anti-adipogenic activities of a mixture ofL.,L., andwere investigated and their anti-obesity activities were established in vitro and. Among the 26 different mixtures of extraction solvent and mixture ratios, ethanol extract mixture no. 1 (EM01) showed the highest antioxidant (α,α-Diphenyl-β-picrylhydrazyl, total phenolic contents) and anti-adipogenic (Oil-Red O staining) activities. EM01 inhibited lipid accumulation in 3T3-L1 adipocytes compared to quercetin-3-O-glucuronide. Furthermore, body, liver, and adipose tissue weights decreased in the high-fat diet (HFD)-EM01group compared to in the high-fat diet control group (HFD-CTL). EM01 lowered blood glucose levels elevated by the HFD. Lipid profiles were improved following EM01 treatment. Serum adiponectin significantly increased, while leptin, insulin growth factor-1, non-esterified fatty acid, and glucose significantly decreased in the HFD-EM01 group. Adipogenesis and lipogenesis-related genes were suppressed, while fat oxidation-related genes increased following EM01 administration. Thus, EM01 may be a natural anti-obesity agent.