[Therapeutic effect of combined therapy of Salvia miltiorrhizae and Polyporus umbellatus polysaccharide in the treatment of chronic hepatitis B].
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1993 Sep;13(9):533-5, 516-7. PMID: 8111209
90 patients of chronic hepatitis B with positive HBV replication markers and abnormality of ALT were randomly allocated to 3 groups. 30 cases were treated with Salvia miltiorrhizae (SM) and Polyporus Umbellatus polysaccharide (PUP) as group I, 30 cases were treated with SM solely as group II and 30 cases were treated with PUP only as group III. By the end of 3 months in the treatment course, normalization rate of ALT were 80.0%, 40.0% and 53.3% and the negative conversion rate of HBeAg were 56.7%, 50.0% and 16.7% in the group I, II and III respectively. Follow up for 3 months after the end of therapy, ALT level was normal in 82.6%, 42.7% and 59.1% respectively. HBeAg was negative in 60.9%, 52.4% and 22.7%. Follow up for 9 months after the end of the treatment, ALT was normal in 83.3%, 43.8% and 56.3%. HBeAg was negative in 66.7%, 56.3% and 25.0% respectively. These results showed that combined therapy with SM and PUP might be more potent than SM and PUP therapy alone.