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Article Publish Status: FREE
Abstract Title:

inhibits itch-associated histamine and IL-31 production in stimulated mast cells.

Abstract Source:

Exp Ther Med. 2019 Sep ;18(3):1914-1920. Epub 2019 Jul 1. PMID: 31410154

Abstract Author(s):

Jae Young Shin, Denis Nchang Che, Byoung Ok Cho, Hyun Ju Kang, Jisu Kim, Seon Il Jang

Article Affiliation:

Jae Young Shin

Abstract:

(Myrrh) is widely recognized for its anti-inflammatory and antimicrobial properties, which are utilized for the treatment of oral ulcers, gingivitis, sinusitis, glomerulonephritis, brucellosis and a variety of skin disorders. The current study aimed to assess whether myrrh modulates itch-associated interleukin (IL)-31 cytokine production and histamine release in stimulated human mast cells (HMC-1). To realize this, molecular biology techniques including real-time quantitiative PCR, western blotting and ELISA were employed. The results indicated that Myrrh successfully suppressed phorbol myristate acetate and calcium ionophore-stimulated mRNA expression, and reduced the production of IL-31 in HMC-1 cells. In addition, myrrh served as a suppressor of extracellular signal-regulated kinase and NF-κB activation, indicating its mechanism in the prevention of HMC-1 cell IL-31 production. Myrrh also prevented the release of histamine in HMC-1 cells. Whilst the present study awaitssupport, the pharmacological actions of myrrh provide new indications as to its potential applicability for itch treatment, which cannot be treated with histamine receptor blockers alone.

Study Type : In Vitro Study

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Sayer Ji
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