Article Publish Status: FREE
Abstract Title:

Comparison of the Antimicrobial Activities of Four Honeys From Three Countries (New Zealand, Cuba, and Kenya).

Abstract Source:

Front Microbiol. 2018 ;9:1378. Epub 2018 Jun 25. PMID: 29988499

Abstract Author(s):

Gianluca Morroni, José M Alvarez-Suarez, Andrea Brenciani, Serena Simoni, Simona Fioriti, Armanda Pugnaloni, Francesca Giampieri, Luca Mazzoni, Massimiliano Gasparrini, Emanuela Marini, Marina Mingoia, Maurizio Battino, Eleonora Giovanetti

Article Affiliation:

Gianluca Morroni


Skin and chronic wound infections are an increasing and urgent health problem worldwide. Their management is difficult and the development of antibiotic resistance by both planktonic and biofilm-associated bacteria necessitates the use of alternative treatments. The purpose of this study was to compare the antimicrobial activity of four honeys from different floral and geographical origins:honey (Cuba) and threehoneys [Manuka honey (New Zealand),honey (Cuba), and African honey (Kenya)]. The physicochemical parameters were within the ranges reported for these honeys andhoney stood out due to its acidic character. An agar incorporation technique was used to determine the minimum active dilution of each honey against 52 clinical isolates (34 Gram-positive, 17 Gram-negative, and 1). The antibiofilm activity of honeys was tested by assessing their ability to inhibit biofilm formation and to disrupt preformed biofilms. Overall,honey had the highest antimicrobial and antibiofilm activity, although a marked disruption in preformed biofilms was shared by all tested honeys. Structural changes induced byhoney onandcells were observed by transmission electron microscopy suggesting that this honey has a potent antimicrobial action and may be an excellent candidate for the development of topical preparations for the treatment of infected wounds.

Study Type : In Vitro Study

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