The relative toxicity of compounds used as preservatives in vaccines and biologics.
Med Sci Monit. 2010 Apr 28;16(5):SR21-7. PMID: 20424565
CoMeD, Inc., Silver Spring, MD, USA.
BACKGROUND: In vaccines/biologics, preservatives are used to prevent microbial growth. MATERIAL/METHODS: The present study examined: (1) the comparative toxicities of commonly used preservatives in US licensed vaccines to human neurons; and (2) the relative toxicity index of these compounds to human neurons in comparison to bacterial cells. RESULTS: Using human neuroblastoma cells, the relative cytotoxicity of the levels of the compounds commonly used as preservative in US licensed vaccines was found to be phenol<2-phenoxyethanol