Abstract Title:

Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds.

Abstract Source:

Explore (NY). 2007 Nov-Dec;3(6):573-84. PMID: 17998162

Abstract Author(s):

Hyun Sook Kwon, Min-Jung Kim, Hyung Jae Jeong, Min Suk Yang, Ki Hun Park, Tae-Sook Jeong, Woo Song Lee


Six diarylbutane lignans 1-5 and one aryltetralin lignan 6 were isolated from the methanol (95%) extracts of Myristica fragrans seeds and then 7-methyl ether diarylbutane lignan 4 has proven to be new a compound. Their compounds 1-7 were evaluated for LDL-antioxidant activity to identify the most potent LDL-antioxidant 3 with an IC50 value of 2.6 microM in TBARS assay. Due to its potency, compound 3 was tested for complementary in vitro investigations, such as lag time (140 min at 1.0 microM), relative electrophoretic mobility (REM) of ox-LDL (inhibition of 80% at 20 microM and 72% at 10 microM), and fragmentation of apoB-100 (inhibition of 93% at 20 microM) on copper-mediated LDL oxidation. In macrophage-mediated LDL oxidation, the TBARS formation was also inhibited by compound 3. 

Study Type : In Vitro Study

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