Compounds within bay leaf prevent blood ethanol elevation and retard gastric emptying. - GreenMedInfo Summary
Preventive effect of sesquiterpenes from bay leaf on blood ethanol elevation in ethanol-loaded rat: structure requirement and suppression of gastric emptying.
Bioorg Med Chem Lett. 1999 Sep 20;9(18):2647-52. PMID: 10509909
Kyoto Pharmaceutical University, Japan.
The methanolic extract from the leaves of Laurus nobilis (bay leaf, laurel) potently inhibited the elevation of blood ethanol level in ethanol-loaded rat. Through bioassay-guided separation, costunolide, dehydrocostus lactone, and santamarine were isolated as the active constituents and the alpha-methylene-gamma-butyrolactone structure was found to be essential for the preventive effect on ethanol absorption. In addition, the retardation of gastric emptying seemed to be partially involved in the preventive effects.