Article Publish Status: FREE
Abstract Title:

Antimalarial evaluation of the chemical constituents of hairy root culture of Bixa orellana L.

Abstract Source:

Molecules. 2013 ;19(1):756-66. Epub 2014 Jan 8. PMID: 24406786

Abstract Author(s):

Bo Zhai, Julie Clark, Taotao Ling, Michele Connelly, Fabricio Medina-Bolivar, Fatima Rivas

Article Affiliation:

Bo Zhai

Abstract:

Over 216 million malaria cases are reported annually worldwide and about a third of these cases, primarily children under the age of five years old, will not survive the infection. Despite this significant world health impact, only a limited number of therapeutic agents are currently available. The lack of scaffold diversity poses a threat in the event that multi-drug-resistant strains emerge. Terrestrial natural products have provided a major source of chemical diversity for starting materials in many FDA approved drugs over the past century. Bixa orellana L. is a popular plant used in South America for the treatment of malaria. In search of new potential therapeutic agents, the chemical constituents of a selected hairy root culture line of Bixa orellana L. were characterized utilizing NMR and mass spectrometry methods, followed by its biological evaluation against malaria strains 3D7 and K1. The crude extract and its isolated compounds demonstrated EC50 values in the micromolar range. Herein, we report our findings on the chemical constituents of Bixa orellana L. from hairy roots responsible for the observed antimalarial activity.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antimalarials : CK(41) : AC(24)

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