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Abstract Title:

Chemical Constituents of Propolis from Vietnamese Trigona minor and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line.

Abstract Source:

J Nat Prod. 2017 Aug 7. Epub 2017 Aug 7. PMID: 28783356

Abstract Author(s):

Hai X Nguyen, Mai T T Nguyen, Nhan T Nguyen, Suresh Awale

Article Affiliation:

Hai X Nguyen

Abstract:

The ethanol extract of propolis from the Vietnamese stingless bee Trigona minor possessed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells in nutrient-deprived medium, with a PC50 value of 14.0μg/mL. Chemical investigation of this extract led to the isolation of 15 cycloartane-type triterpenoids, including five new compounds (1-5), and a lanostane-type triterpenoid. The structures of the new compounds were elucidated on the basis of NMR spectroscopic analysis. Among the isolated compounds, 23-hydroxyisomangiferolic acid B (5) and 27-hydroxyisomangiferolic acid (13) exhibited the most potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived conditions, with PC50 values of 4.3 and 3.7 μM, respectively.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Cytotoxic : CK(76) : AC(60)

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