Abstract Title:

Contamination status of bisphenol A and its analogues (bisphenol S, F and B) in foodstuffs and the implications for dietary exposure on adult residents in Zhejiang Province.

Abstract Source:

Food Chem. 2019 Oct 1 ;294:160-170. Epub 2019 May 6. PMID: 31126448

Abstract Author(s):

Jian Zhou, Xiao-Hong Chen, Sheng-Dong Pan, Jun-Lin Wang, Yi-Bin Zheng, Jiao-Jiao Xu, Yong-Gang Zhao, Zeng-Xuan Cai, Mi-Cong Jin

Article Affiliation:

Jian Zhou


An effective method has been developed for the simultaneous determination of four bisphenols (bisphenol A, S, F and B) in various foodstuffs. The contaminants were extracted by QuEChERS-based strategy and subjected to ion-exchange solid-phase extraction for further clean-up. The critical variables were screened by Plackett-Burman design and then optimized by central composite design. Under the optimized conditions, satisfactory accuracy (recoveries 76%-116%) and precision (RSDs < 12%) were achieved. The established method was then used to assess the contamination status of 379 real samples. Bisphenol A was demonstrated to be the predominant bisphenol with highest incidence (79.7%) and average concentration (14.3 μg/kg). The positive rates (mean concentration) of bisphenol S, F and B were 37.7% (1.6 μg/kg), 26.9% (1.4 μg/kg) and 0.0% (not detected), respectively. Finally, the daily dietary intakes of ∑bisphenolsfor adult residents were estimated (55.9-76.1 ng/kg bw/day) according to the contamination concentrations and the daily recommended intakes.

Study Type : Human Study

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