Contribution of momilactones A and B to diabetes inhibitory potential of rice bran. - GreenMedInfo Summary
Contribution of momilactones A and B to diabetes inhibitory potential of rice bran: Evidence from in vitro assays.
Saudi Pharm J. 2019 Jul ;27(5):643-649. Epub 2019 Mar 15. PMID: 31297018
Nguyen Van Quan
This study was the first to detect the presence of the two compounds momilactone A (MA) and momilactone B (MB) in rice bran using liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS). By in vitro assays, both MA and MB exhibited potent inhibitory activities on pancreaticα-amylase and α-glucosidase which were significantly higher than γ-oryzanol, a well-known diabetes inhibitor. Remarkably, MA and MB indicated an effective inhibition on trypsin with the ICvalues of 921.55 and 884.03 µg/mL, respectively. By high-performance liquid chromatography (HPLC), quantities of MA (6.65 µg/g dry weight) and MB (6.24 µg/g dry weight) in rice bran were determined. Findings of this study revealed the α-amylase, α-glucosidase and trypsin inhibitors MA and MB contributed an active role to the diabetes inhibitory potential of rice bran.