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Article Publish Status: FREE
Abstract Title:

Cordifolioside: potent inhibitor against Mof SARS-CoV-2 and immunomodulatory through human TGF-β and TNF-α.

Abstract Source:

3 Biotech. 2021 Mar ;11(3):136. Epub 2021 Feb 22. PMID: 33643762

Abstract Author(s):

Munikumar Manne, Giridhar Goudar, Seshadri Reddy Varikasuvu, Mahadev C Khetagoudar, Hema Kanipakam, Pradeep Natarajan, Muni Divya Ummiti, Vijay Aravind Yenagi, Sridhar Chinthakindi, Prakash Dharani, Durga Sai Sri Thota, Sameer Patil, Vijaylaxmi Patil

Article Affiliation:

Munikumar Manne

Abstract:

Therapeutic options for SARS-CoV-2 are limited merely to the symptoms or repurposed drugs and non-specific interventions to promote the human immune system. In the present study, chromatographic and in silico approaches were implemented to identify bioactive compounds which might play pivotal role as inhibitor for SARS-CoV-2 and human immunomodulator (TGF-β and TNF-α).(Willd.) Miers was evaluated for phenolic composition and explored for bioactive compounds by high-performance thin layer chromatography (HPTLC). Furthermore, the bioactive compounds such as cordifolioside, berberine, and magnoflorine were appraised as human immunomodulatory and potent inhibitor against Main Protease (M) of SARS-CoV-2 through multiple docking strategies. Cordifolioside formed six stable H-bonds with His41, Ser144, Cys145, His163, His164, and Glu166 of Mof SARS-CoV-2, which displayed a significant role in the viral replication/transcription during infection acting towards the common conserved binding cleft among all strains of coronavirus. Overall, the study emphasized that the proposed cordifolioside might use for future investigations, which hold as a promising scaffold for developing anti-COVID-19 drug and reduce human cytokine storm.

Study Type : In Vitro Study

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