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Article Publish Status: FREE
Abstract Title:

Immunostimulating activity of maysin isolated from corn silk in murine RAW 264.7 macrophages.

Abstract Source:

BMB Rep. 2014 Jul ;47(7):382-7. PMID: 24286330

Abstract Author(s):

Jisun Lee, Sun-Lim Kim, Seul Lee, Mi Ja Chung, Yong Il Park

Article Affiliation:

Jisun Lee

Abstract:

Corn silk (CS) has long been consumed as a traditional herb in Korea. Maysin is a major flavonoid of CS. The effects of maysin on macrophage activation were evaluated, using the murine macrophage RAW 264.7 cells. Maysin was isolated from CS by methanol extraction, and preparative C18 reverse phase column chromatography. Maysin was nontoxic up to 100μg/ml, and dose-dependently increased TNF-α secretion and iNOS production by 11.2- and 4.2-fold, respectively, compared to untreated control. The activation and subsequent nuclear translocation of NF-κB was substantially enhanced upon treatment with maysin (1-100 μg/ml). Maysin also stimulated the phosphorylation of Akt and MAPKs (ERK, JNK). These results indicated that maysin activates macrophages to secrete TNF-α and induce iNOS expression, via the activation of the Akt, NF-κB and MAPKs signaling pathways. These results suggest for the first time that maysin can be a new immunomodulator, enhancing the early innate immunity.

Study Type : In Vitro Study

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Sayer Ji
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