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Article Publish Status: FREE
Abstract Title:

Cost Effective Use of a Thiosulfinate-EnrichedExtract in Combination with Chemotherapy in Colon Cancer.

Abstract Source:

Int J Mol Sci. 2020 Apr 16 ;21(8). Epub 2020 Apr 16. PMID: 32316312

Abstract Author(s):

Jose Manuel Perez-Ortiz, Eva Maria Galan-Moya, Miguel Angel de la Cruz-Morcillo, Juan Francisco Rodriguez, Ignacio Gracia, Maria Teresa Garcia, Francisco Javier Redondo-Calvo

Article Affiliation:

Jose Manuel Perez-Ortiz

Abstract:

In this work, we sought to investigate the effects of a thiosulfinate-enriched garlic extract, co-administered with 5-fluorouracil (5-FU) or oxaliplatin chemotherapy, on the viability of colon cancer cells (Caco-2 and HT-29). We also addressed the economic feasibility of a new combined treatment of this thiosulfinate-enriched garlic extract, with oxaliplatin that could reduce the dosage and costs of a monotherapy. The thiosulfinate-enriched garlic extract not only enhanced the impact of 5-FU and oxaliplatin (500µM) in decreasing Caco-2 and HT-29 viability, but also showed a higher effect than standard 5-FU and oxaliplatin chemotherapy as anti-cancer agents. These results provided evidences for the combination of lyophilized garlic extract and 5-FU or oxaliplatin as a novel chemotherapy regimen in colon cancer cells that may also reduce the clinical therapy costs.

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