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Article Publish Status: FREE
Abstract Title:

Crocetin Alleviates Inflammation in MPTP-Induced Parkinson's Disease Models through Improving Mitochondrial Functions.

Abstract Source:

Parkinsons Dis. 2020 ;2020:9864370. Epub 2020 Oct 10. PMID: 33101635

Abstract Author(s):

Na Dong, Zhong Dong, Ying Chen, Xiaosu Gu

Article Affiliation:

Na Dong

Abstract:

Parkinson's disease (PD) is the second most common neurodegenerative disease. Crocetin, derived from saffron, exerts multiple pharmacological properties, such as anti-inflammatory, antioxidant, antifatigue, and anticancer effects. However, the effect of crocetin on PD remains unclear. In this study, we designed experiments to investigate the effect of crocetin against MPTP-induced PD models and the underlying mechanisms. Our results showed that crocetin treatment attenuates MPTP-induced motor deficits and protects dopaminergic neurons. Bothandexperiments demonstrated that crocetin treatment decreased the expression of inflammatory associated genes and inflammatory cytokines. Furthermore, crocetin treatment protected mitochondrial functions against MPP+ induced damage by regulating the mPTP () viability in the interaction of ANT () and Cyp D () dependent manner. Therefore, our results demonstrate that crocetin has therapeutic potential in Parkinson's disease.

Study Type : Animal Study, In Vitro Study

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