n/a
Abstract Title:

Comparative anticancer activity analysis of saffron extracts and a principle component, crocetin for prevention and treatment of human malignancies.

Abstract Source:

J Food Sci Technol. 2019 Dec ;56(12):5435-5443. Epub 2019 Aug 17. PMID: 31749491

Abstract Author(s):

Sevgi Gezici

Article Affiliation:

Sevgi Gezici

Abstract:

Abstract: Saffron, obtained from dry stigmas of the flowers ofL. (fam. Iridaceae), is an ancient spice and a natural food colorant that has been used to treat various diseases in the long human history. Crocetin is of the main secondary metabolites of saffron and its curative properties for many ailments have been revealed in the previous scientific reports. The aim of this study was to evaluate the anticancer potentials of saffron extracts and its pure crocetin compounds against human cancer cells. The cytotoxic and antiproliferative activities along with lactate dehydrogenase activities of extracts and crocetin, a carotenoid derived from saffron, were assessed using A549, MCF-7 and HeLa human cancer cells, and compared to the non-malignant HUVECs. Additionally, apoptotic activity in the cells treated and untreated with the extracts and pure crocetin were determined in terms of DNA fragmentation. The results showed the extracts and crocetin from saffron induced cytotoxicity, enhanced cancer cell death as well as inhibited cancer cell growth in a concentration and time dependent manner. In addition, the results revealed that the tested compounds at different concentration had no cytotoxic effects on the non-malignant cells, whereas, it could significantly decrease the cell viability and proliferation in the malignant cells. As compared to anticancer potentials of the analyzed extracts and its pure crocetin compounds, crocetin was found as the more potent one. Overall, this research suggests that crocetin is a potential anticancer agent that can be used for cancer prevention and treatment.

Graphic abstract:

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.