Cucumol B has cytotoxic effects toward ovarian and human breast adenocarcinoma. - GreenMedInfo Summary
Cucumol B, a new triterpene benzoate fromseeds with cytotoxic effect toward ovarian and human breast adenocarcinoma.
J Asian Nat Prod Res. 2019 Nov ;21(11):1112-1118. Epub 2018 Jun 27. PMID: 29947257
Sabrin Ragab Mohamed Ibrahim
Phytochemical investigation of the methanolic extract ofL. (Cucurbitaceae) seeds furnished a new triterpene benzoate derivative: cucumol B () and four known flavonoids: quercetin-3---D-glucopyranosyl-(1→6)--L-rhamnopyranoside (), quercetin-3---D-glucopyranoside (), quercetin (), and luteolin (). Their structures were identified by UV, IR, 1D (C andH), 2D (HSQC,H-H COSY, HMBC, and NOESY) NMR, and HRESIMS spectral as well as comparing with literature data. Compoundhas been assessed for thecytotoxic effect against SKOV-3, MCF-7, and HCT-116 cell lines. It had selective and potent effect toward SKOV-3 and MCF-7 cell lines with ICs 2.05 and 0.41 μM, respectively, in comparison to doxorubicin (ICs 0.32 and 0.05 μM). However, it showed moderate activity toward HCT-116 cell line with IC8.27 μM.