Abstract Title:

Cucurbitacin B induces apoptosis and S phase cell cycle arrest in BEL-7402 human hepatocellular carcinoma cells and is effective via oral administration.

Abstract Source:

Cancer Lett. 2010 Aug 1 ;294(1):118-24. Epub 2010 Feb 11. PMID: 20153103

Abstract Author(s):

Kin Tak Chan, Fan Yan Meng, Qian Li, Cheong Yip Ho, Tsz Shan Lam, Yu To, Wai Him Lee, Miao Li, Kee Hung Chu, Melvin Toh

Article Affiliation:

Kin Tak Chan

Abstract:

Cucurbitacin B is an anti-cancer drug candidate and its efficacy has been demonstrated in hepatocellular carcinoma (HCC). To explore its mechanism against HCC, BEL-7402 cells were treated with cucurbitacin B in vitro. Treatment with cucurbitacin B induced S phase arrest and apoptosis. The growth inhibition effect was associated with cyclin D1 and cdc-2 down regulations. Western blotting analysis of cell signaling molecules indicated that cucurbitacin B inhibited c-Raf activation without affecting STAT3 phosphorylation. Moreover, in vivo study demonstrated that cucurbitacin B is effective against BEL-7402 xenograft when administrated orally.

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Sayer Ji
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