normalized cimetidine-induced pituitary-testicular dysfunction: Relevance in nutraceutical therapy.
Animal Model Exp Med. 2019 Sep ;2(3):191-200. Epub 2019 Sep 2. PMID: 31773095
Ngozi Joy Onwuemene
Background: The increasing incidence of chemically induced infertility is both a social threat and a threat to the continuation of life itself. Treatment or management therapy is often expensive. This study investigated the effects of acetone extract of a local plant () in a Wistar rat model of cimetidine-induced pituitary-testicular dysfunction.
Methods: Thirty-five male Wistar rats were divided into 7 groups of 5 rats. After a phytochemical screening of an acetone extract of, cimetidine and the extract at three doses, 200, 400 and 600 mg/kg, were orally co-administered to the rats for 28 consecutive days. Comparisons were made (at < 0.05) against a control (2 mL/kg distilled water), a standard treatment group (cimetidine + 50 mg/kg vitamin C), a toxic group (60 mg/kg cimetidine) and a group receiving extract alone.
Results: Cimetidine administration was associated with deleterious alterations to sperm motility, sperm count and sperm viability, as well as derangements in the plasma levels of FSH, LH and testosterone ( < 0.05). Both brain and testicular GSH and TBARS levels were significantly altered following cimetidine administration, and distortions were seen in the pituitary and testicular histoarchitecture. These changes were significantly normalized by co-administration of graded doses of the extract, with an associated improvement of both pituitary and testicular histology.
Conclusion: Acetone extract ofnormalized cimetidine-induced pituitary-testicular dysfunction in Wistar rats. This presents the extract as a potential nutraceutical choice against chemically induced reproductive toxicity.