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Article Publish Status: FREE
Abstract Title:

Herbal Composition LI73014F2 Alleviates Articular Cartilage Damage and Inflammatory Response in Monosodium Iodoacetate-Induced Osteoarthritis in Rats.

Abstract Source:

Molecules. 2020 Nov 23 ;25(22). Epub 2020 Nov 23. PMID: 33238379

Abstract Author(s):

Hae Lim Kim, Hae Jin Lee, Dong-Ryung Lee, Bong-Keun Choi, Seung Hwan Yang

Article Affiliation:

Hae Lim Kim

Abstract:

The aim of this study was to determine the anti-osteoarthritic effects of LI73014F2, which consists offruit,rhizome, andgum resin in a 2:1:2 ratio, in the monosodium iodoacetate (MIA)-induced osteoarthritis (OA) rat model. LI73014F2 was orally administered once per day for three weeks. Weight-bearing distribution and arthritis index (AI) were measured once per week to confirm the OA symptoms. Synovial membrane, proteoglycan layer, and cartilage damage were investigated by histological examination, while synovial fluid interleukin-1β level was analyzed using a commercial kit. Levels of pro-inflammatory mediators/cytokines and matrix metalloproteinases (MMPs) in the cartilage tissues were investigated to confirm the anti-osteoarthritic effects of LI73014F2. LI73014F2 significantly inhibited the MIA-induced increase in OA symptoms, synovial fluid cytokine, cartilage damage, and expression levels of pro-inflammatory mediators/cytokines and MMPs in the articular cartilage. These results suggest that LI73014F2 exerts anti-osteoarthritic effects by regulating inflammatory cytokines and MMPs in MIA-induced OA rats.

Study Type : Animal Study

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