Abstract Title:

Design and development of curcumin bioconjugates as antiviral agents.

Abstract Source:

Nucleic Acids Symp Ser (Oxf). 2008(52):599-600. PMID: 18776522

Abstract Author(s):

Diwakar Rai, Dipti Yadav, J Balzarini, E De Clercq, Ramendra K Singh

Article Affiliation:

Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad-211002, India.


A number of curcumin bioconjugates with fatty acid, dipeptide and folic acid, viz. di-O-decanoyl curcumin (2), di-O-tryptophanylphenylalanine curcumin (3), di-O-bis-(gamma, gamma)folyl curcumin (4), C(4)-ehyl-O-gamma-folyl curcumin (5) and 4-O-ethyl-O-gamma-folyl curcumin (6) have been synthesized. Conjugates 2-6 have shown good antiviral property with EC(50) ranging between 0.019-0.105 microM against a wide range of viruses, like HIV, HSV, VSV and many others.

Study Type : Review

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