Curcumin can decrease inflammation in an experimental model of fibrosis. - GreenMedInfo Summary
[Effects of curcumin on TNF-alpha and TGF-beta1 in serum and lung tissue of SiO2-induced fibrosis in mice].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009 May;25(5):399-401. PMID: 19426594
Department of Microbiology and Immunology, Jinan University, Guangzhou, China. [email protected]
AIM: To study the effects of curcumin on TNF-alpha and TGF-beta1 in serum and lung tissue of SiO2-induced fibrosis in mice.
METHODS: 75 mice were divided into five groups. After treated with curcumin 6 and 9 mice of each group were sacrificed on day 14 and 42 respectively to take their blood and lung tissue. The level of TNF-alpha and TGF-beta1 was observed by ELISA.
RESULTS: The infection reaction of lung tissue and fibrosis in model group was obvious. Compared with sham operation group, TNF-alpha and TGF-beta1 in serum and lung tissue increased significantly(P<0.01), but decreased in different degrees after treated with curcumin(P<0.05).
CONCLUSION: Curcumin can decrease the level of TNF-alpha and TGF-beta1 in serum and lung tissue of SiO2-induced fibrosis in mice and have the anti-fibrosis role by deregulating cytokine level.