Abstract Title:

Curcumin inhibits human lung large cell carcinoma cancer tumour growth in a murine xenograft model.

Abstract Source:

Phytother Res. 2010 Jan 13;24(2):189-192. Epub 2010 Jan 13. PMID: 20077433

Abstract Author(s):

Chin-Cheng Su, Jai-Sing Yang, Chi-Cheng Lu, Jo-Hua Chiang, Chang-Lin Wu, Jen-Jyh Lin, Kuang-Chi Lai, Te-Chun Hsia, Hsu-Feng Lu, Ming-Jen Fan, Jing-Gung Chung

Abstract:

Curcumin can decrease viable cells through the induction of apoptosis in human lung cancer NCI-H460 cells in vitro. However, there are no reports that curcumin can inhibit cancer cells in vivo. In this study, NCI-H460 lung tumour cells were implanted directly into nude mice and divided randomly into four groups to be treated with vehicle, curcumin (30 mg/kg of body weight), curcumin (45 mg/kg of body weight) and doxorubicin (8 mg/kg of body weight). Each agent was injected once every 4 days intraperitoneally (i.p.), with treatment starting 4 weeks after inoculation with the NCI-H460 cells. Treatment with 30 mg/kg and 45 mg/kg of curcumin or with 8 mg/kg of doxorubicin resulted in a reduction in tumour incidence, size and weight compared with the control group. The findings indicate that curcumin can inhibit tumour growth in a NCI-H460 xenograft animal model in vivo. Copyright (c) 2010 John Wiley&Sons, Ltd.

Study Type : Transgenic Animal Study

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