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Abstract Title:

[The relationship between the effects of curcumin on cerebral ischemia/reperfusion injury and immediately genic expressions of fos, Jun and NF-kappaB in hippocampal CA1 area and its significance in gerbils].

Abstract Source:

Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2007 May;23(2):184-8. PMID: 21179765

Abstract Author(s):

Hong Cao, Jun Li, Guang-ming Li, Yao-qi Wang, Yin-ming Zeng

Article Affiliation:

Department of Anesthesiology, 2nd Affiliated Hospital of Wenzhou Medical College, Zhejiang 325027, China.

Abstract:

AIM: To explore the relationship between the effects of curcumin on cerebral ischemic/reperfusion injury and immediately genic expressions of Fos, Jun and NF-kappaB in hippocampal CA1 area.

METHODS: Gerbils were randomly divided into sham group (SH), ischemia/reperfusion group (I/R), curcumin group (CU) and solvent control group (SC). Forebrain ischemia was induced by occlusion of bilateral common carotid arteries. Observations were carried out in each group 15 min, 1 h, 2 h, 6 h, 1 d, 3 d, 5 d and 7 d after ischemia: open field test was used to examine the behavioral change, the apoptosis neurons in hippocampal CA1 region was counted, the expression of Fos, Jun and NF-kappaB in hippocampal CA1 was detected by SABC immunocytochemical technique.

RESULTS: The behavioral mark and the number of apoptosis neurons in hippocampal (CA1 region was much less in CU group than in I/R group (P<0.01) The expression of Fos was more and the expression of Jun and NF-kappaB was less in CA1 area in CU group than in I/R group (P<0.01).

CONCLUSION: Curcumin can significantly protect neurons against cerebral ischemia, increasing the expression Fos and decreasing the expression of Jun and NF-kappaB may be the protective mechanisms.

Study Type : Animal Study

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