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Article Publish Status: FREE
Abstract Title:

Curcumin Attenuates Gentamicin-Induced Kidney Mitochondrial Alterations: Possible Role of a Mitochondrial Biogenesis Mechanism.

Abstract Source:

Evid Based Complement Alternat Med. 2015 ;2015:917435. Epub 2015 Aug 5. PMID: 26345660

Abstract Author(s):

Mario Negrette-Guzmán, Wylly Ramsés García-Niño, Edilia Tapia, Cecilia Zazueta, Sara Huerta-Yepez, Juan Carlos León-Contreras, Rogelio Hernández-Pando, Omar Emiliano Aparicio-Trejo, Magdalena Madero, José Pedraza-Chaverri

Article Affiliation:

Mario Negrette-Guzmán

Abstract:

It has been shown that curcumin (CUR), a polyphenol derived from Curcuma longa, exerts a protective effect against gentamicin- (GM-) induced nephrotoxicity in rats, associated with a preservation of the antioxidant status. Although mitochondrial dysfunction is a hallmark in the GM-induced renal injury, the role of CUR in mitochondrial protection has not been studied. In this work, LLC-PK1 cells were preincubated 24 h with CUR and then coincubated 48 h with CUR and 8 mM GM. Treatment with CUR attenuated GM-induced drop in cell viability and led to an increase in nuclear factor (erythroid-2)-related factor 2 (Nrf2) nuclear accumulation and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) cell expression attenuating GM-induced losses in these proteins. In vivo, Wistar rats were injected subcutaneously with GM (75 mg/Kg/12 h) during 7 days to develop kidney mitochondrial alterations. CUR (400 mg/Kg/day) was administered orally 5 days before and during the GM exposure. The GM-induced mitochondrial alterations in ultrastructure and bioenergetics as well as decrease in activities of respiratory complexes I and IV and induction of calcium-dependent permeability transition were mostly attenuated by CUR. Protection of CUR against GM-induced nephrotoxicity could bein part mediated by maintenance of mitochondrial functions and biogenesis with some participation of the nuclear factor Nrf2.

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Sayer Ji
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