Abstract Title:

Protective effect of curcumin during selenium induced toxicity on dehydrogenases in hepatic tissue.

Abstract Source:

Indian J Physiol Pharmacol. 2005 Jan;49(1):111-4. PMID: 15881869

Abstract Author(s):

S Padmaja, T N Raju

Article Affiliation:

Physiology Division, Department of Zoology, University College of Science, Osmania University, Hyderabad - 500 007.


Selenium administration resulted in a marked decrease in the activity levels of the liver succinate dehydrogenase, malate dehydrogenase, and lactate dehydrogenase while pyruvate dehydrogenase increased significantly (P<0.001) in the wistar rat. The degree of decrease of these enzymes was significantly less (P<0.001) when rats were treated with curcumin, a natural constituent Curcuma longa. Curcumin seems to prevent oxidative damage mediated through selenium and protect the dehydrogenases possibly through its anti-oxidative property.

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