Abstract Title:

Neuroprotective effect of curcumin in arsenic-induced neurotoxicity in rats.

Abstract Source:

Neurotoxicology. 2010 Sep;31(5):533-9. Epub 2010 May 11. PMID: 20466022

Abstract Author(s):

Rajesh S Yadav, Rajendra K Shukla, Madhu Lata Sankhwar, Devendra K Patel, Reyaz W Ansari, Aditya B Pant, Fakhrul Islam, Vinay K Khanna

Article Affiliation:

Indian Institute of Toxicology Research (A Constituent Laboratory of Council of Scientific and Industrial Research, New Delhi), Post Box 80, MG Marg, Lucknow 226001, India.


Our recent studies have shown that arsenic-induced neurobehavioral toxicity is protected by curcumin by modulating oxidative stress and dopaminergic functions in rats. In addition, the neuroprotective effect of curcumin has been investigated on arsenic-induced alterations in biogenic amines, their metabolites and nitric oxide (NO), which play an important role in neurotransmission process. Decrease in the levels of dopamine (DA, 28%), norepinephrine (NE, 54%), epinephrine (EPN, 46%), serotonin (5-HT, 44%), 3,4-dihydroxyphenylacetic acid (DOPAC, 20%) and homovanillic acid (HVA, 31%) in corpus striatum; DA (51%), NE (22%), EPN (47%), 5-HT (25%), DOPAC (34%) and HVA (41%) in frontal cortex and DA (35%), NE (35%), EPN (29%), 5-HT (54%), DOPAC (37%) and HVA (46%) in hippocampus, observed in arsenic (sodium arsenite, 20 mg/kg body weight, p.o., 28 days) treated rats exhibited a trend of recovery in rats simultaneously treated with arsenic and curcumin (100 mg/kg body weight, p.o., 28 days). Increased levels of NO in corpus striatum (2.4-fold), frontal cortex (6.1-fold) and hippocampus (6.2-fold) in arsenic-treated rats were found decreased in rats simultaneously treated with arsenic and curcumin. It is evident that curcumin modulates levels of brain biogenic amines and NO in arsenic-exposed rats and these results further strengthen its neuroprotective efficacy.

Study Type : Animal Study

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