Abstract Title:

Curcumin Modulates Muscle Damage but not Oxidative Stress and Antioxidant Defense Following Eccentric Exercise in Rats.

Abstract Source:

Int J Vitam Nutr Res. 2014 ;84(3-4):163-72. PMID: 26098480

Abstract Author(s):

Ismail Boz, Muaz Belviranli, Nilsel Okudan

Article Affiliation:

Ismail Boz

Abstract:

AIM: The purpose of this study was to investigate the effects of curcumin on eccentric exercise-induced muscle damage and oxidative stress in rats.

METHODS: Thirty male Wistar rats were divided into four groups: Control (C; no curcumin, no exercise; n=6), Curcumin (Cur; n=8), Exercise (E; n=8) and Exercise Plus Curcumin (ECur; n=8). Curcumin was given for 20 days via oral gavage at doses of 200 mg/kg(-1) of body weight per day, dissolved in corn oil. On the 21st day eccentric exercise was provided via a treadmill run and the rats were sacrificed immediately after.

RESULTS: Eccentric exercise resulted in significant (p<0.05) increases in all injury markers such as creatine kinase (CK) and myoglobin, but curcumin supplementation tended to decrease CK activity (p>0.05) and significantly decreased myoglobin levels (p<0.05). In blood and muscle samples, malondialdehyde (MDA) levels were not affected by either curcumin or exercise (p>0.05). MDA levels in liver tissue decreased in the ECur group, compared to the control (p<0.05). Superoxide dismutase (SOD) activities and glutathione (GSH) levels were affected by neither curcumin nor exercise (p>0.05), in blood, muscle and liver tissues.

CONCLUSION: The results of this study suggest that curcumin has a protective effect on eccentric exercise induced muscle damage, and that this effect might be independent of oxidative stress and antioxidant systems.

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Sayer Ji
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