Abstract Title:

[Protective effect of curcumin on myocardial ischemia reperfusion injury in rats].

Abstract Source:

Zhong Yao Cai. 2005 Oct;28(10):920-2. PMID: 16479932

Abstract Author(s):

Hong Cheng, Weiguan Liu, Xiaomei Ai

Article Affiliation:

Dept of Pharmacy, Zhongnan Hospital of Wuhan University, Wuhan 430071.


OBJECTIVE: To study the protective effect of curcumin on myocardial reperfusion injury in rats.

METHODS: Myocardial ischemia reperfusion injury model was established by occluding the left anterior descending branch of coronary arter for 60 min and removing the ligation later to reperfuse for 60 min in vivo. Different dose of curcumin were administered by intravenous injection 5 min before the onset of ischemia. The changes of myocardial infarct sizes (MIS), the serum creatine phosphokinase (CK) and lactate dehydrogenase (LDH), the myocardial malondialdehyed (MDA) and free fatty acid (FFA) content, the myocardial super oxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity were measured.

RESULTS: Curcumin (20, 40 mg/kg) reduced the myocardial infarct sizes, the serum CK and LDH activity. The myocardial MDA and FFA content all declined. SOD and GSH-Px activity were increased markedly.

CONCLUSION: Curcumin exerts protective effects on myocardial ischemia reperfusion injury, which may be due to its function of inhibition of lipid peroxidation, augmentation of endogenous antioxidants and improving myocardial metabolism.

Study Type : Animal Study

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