Abstract Title:

Protection of radiation-induced protein damage by curcumin.

Abstract Source:

Biophys Chem. 2001 Aug 30;92(1-2):119-26. PMID: 11527584

Abstract Author(s):

S Kapoor, K I Priyadarsini

Article Affiliation:

Radiation Chemistry and Chemical Dynamics Division, Bhabha Atomic Research Center, Mumbai 400 085, India. sudhirk@apsara.barc.ernet.in


Free radical reactions of lysozyme (Lz), tryptophan and disulfides were studied with curcumin, a lipid-soluble antioxidant from turmeric, in aqueous solution using a pulse radiolysis technique. The binding of curcumin with lysozyme was confirmed using absorption, fluorescence and stopped-flow techniques. The free radicals of curcumin generated after repairing radicals of disulfides, lysozyme and tryptophan absorb at 500-510 nm. Implication of this in evaluating the antioxidant behavior of curcumin in protecting proteins is discussed.

Study Type : In Vitro Study

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