Abstract Title:

Curcumin induces autophagy in ACC-MESO-1 cells.

Abstract Source:

Phytother Res. 2012 Dec ;26(12):1779-83. Epub 2012 Mar 3. PMID: 22388865

Abstract Author(s):

Yoshikane Yamauchi, Yotaro Izumi, Keisuke Asakura, Yuichiro Hayashi, Hiroaki Nomori

Article Affiliation:

Yoshikane Yamauchi

Abstract:

Malignant pleural mesothelioma is known to be widely resistant to therapy and new treatment strategies are needed. Curcumin, which has a long history as a dietary spice is known to suppress the growth of multiple cancer lines, but the effects on mesothelioma cells are not well defined. In the present study we examined the effects of curcumin on ACC-MESO-1, which is a human derived mesothelioma cell line. We found that curcumin dose-dependently reduced cell viability but did not induce apoptosis. Curcumin administration increased LC3B-II/LC3B-I expression, and induced the formation of autophagosomes on electron microscopy. These changes were attenuated by RNA silencing of atg5. From these findings it was speculated that induction of autophagy was at least in part involved in the reduction of cell viability by curcumin.

Study Type : In Vitro Study

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Sayer Ji
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