Curcumin induces programmed cell death in human multidrug-resistant cells. - GreenMedInfo Summary
Curcumin induces caspase-3-independent apoptosis in human multidrug-resistant cells.
Ann N Y Acad Sci. 2002 Nov;973:250-4. PMID: 12485871
Laboratory of Molecular Bases of Aging, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02-093 Warsaw, Poland. firstname.lastname@example.org
Curcumin, the major component of the spice turmeric, used in 50- micro M concentration, induced cell death in multidrug-resistant CEM(P-gp4) and LoVo(P-gp4) cells as well as in their sensitive counterparts as assessed by TUNEL method and morphological observation. In all cells induced to undergo cell death with curcumin, there was no caspase-3 activation because only the unprocessed form of caspase-3 was observed using immunoblotting.