Abstract Title:

Curcumin induces caspase-3-independent apoptosis in human multidrug-resistant cells.

Abstract Source:

Ann N Y Acad Sci. 2002 Nov;973:250-4. PMID: 12485871

Abstract Author(s):

Katarzyna Piwocka, Anna Bielak-Mijewska, Ewa Sikora

Article Affiliation:

Laboratory of Molecular Bases of Aging, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02-093 Warsaw, Poland. kapi@nencki.gov.pl


Curcumin, the major component of the spice turmeric, used in 50- micro M concentration, induced cell death in multidrug-resistant CEM(P-gp4) and LoVo(P-gp4) cells as well as in their sensitive counterparts as assessed by TUNEL method and morphological observation. In all cells induced to undergo cell death with curcumin, there was no caspase-3 activation because only the unprocessed form of caspase-3 was observed using immunoblotting.

Study Type : In Vitro Study

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